Cannabidiol( CBD) is likely best available known cannabinoid in the cannabis bush, along with THC. Although the two complexes share the same roots, they don’t carry the same mannerisms, and their effects on the human body are very different.
THC is the compound that constitutes one high-flown, and does this by fastening to the CB1 receptor in the mentality. It does offer some health benefits thanks to its analgesic, anti-inflammatory and neuroprotective properties, but the side effects often outweigh potential benefits, and this is why THC isn’t regarded as a treatment solution.
CBD on the other hand has a greater affinity to the CB2 receptor, so it interacts differently with the nervous system and doesn’t derive a psychoactive aftermath. Instead, CBD provides several health benefits, such as antioxidant, antiemetic, anticonvulsant and anti-tumoral properties. Moreover, it counteracts the psychoactivity of THC, and acts as a natural antidepressant and neuroprotective agent.
We won’t detail these aspects here, but you can read our previous articles to better understand the positive effects of cannabidiol and about the differences between THC and CBD. And now let’s return to CBD and its activity inside the human body.
Potential side effects of cannabidiol( CBD)
There are dozens of studies that substantiate the effectiveness of this complex in considering numerous circumstances, and most of these studies conclude that the cannabinoid is safe and virtually free of side effects.
This examine paper for example been shown that verified cannabidiol organisation is safe and non-toxic in humans and animals, and doesn’t induce changes on nutrient uptake , nor does it affect physiological constants like the heart rate, body temperature or blood pressure. According to this review, high dosages of up to 1,500 mg/ date of CBD seem to be well stood in humans and 5mg is perfect pets.
However, the study does mention some potential side effect for cannabidiol, such as the restraint of hepatic medication metabolism, or the decline in task of p-glycoprotein. CBD can, certainly, interact with a series of pharmaceuticals, as it restraints the activity of some liver enzymes called cytochrome P450.
This family of enzymes metabolizes most of the doses used in humen, so if one uses high dosages of CBD, the cannabinoid can temporarily counteract the activity of P450 enzymes, and thus adapt the space doses are metabolized inside the body.
For sure, this action of CBD can be regarded as a side effect, but it’s not always a negative idiosyncrasy, as the deactivation of P450 enzymes is one of the mechanisms through which CBD counteracts THC as well. As a side memorandum, grapefruit has a same aftermath on the mentioned liver enzymes.
Another reported side effect of CBD administration is an unpleasant dry sensation in the mouth. This aftermath seems to be caused by the involvement of the endocannabinoid method in the restraint of saliva secretion. A subject is issued by Argentinian researchers back in 2006 showed that cannabinoid receptors( type 1 and 2) operate in the submandibular glands which are responsible for producing saliva. The activating of these receptors modify the salivary creation, leading to opening dryness( likewise referred to as “cotton-mouth” ).
Early research been shown that CBD taken in high dosages may deteriorate earthquake and muscle change in Parkinson’s disease sufferers. Yet, there are also subjects that suggest that cannabidiol is safe and well-tolerated by cases has an impact on this condition.